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14-06-02, Qian Chen mini
Qian Chen is honored by the Chinese Ministry of Education
Research Group: Applied Systems Biology


Selected Research Papers
Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T (2014) 18F-Fluoride positron emission tomography/computed tomography for non-invasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Accepted for publication in Arthritis Research & Therapy.

Kraibooj K, Park H-R, Dahse H-M, Skerka C, Voigt K and Figge MT (2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosisby macrophages as revealed by automated microscopy image analysis. Accepted for publication in Mycoses.
,Authors contributed equally.

Svensson C-M, Krusekopf S, Lücke J, Figge MT (2014) Automated Detection of Circulating Tumour Cells With Naive Bayesian Classifiers. Cytometry Part A 85(6):501-511. doi:10.1002/cyto.a.22471

Hünniger K , Lehnert T, Bieber K, Martin R, Figge MT, Kurzai O (2014) A Virtual Infection Model Quantifies Innate Effector Mechanisms and Candida albicans Immune Escape in Human Blood. PLOS Computational Biology 10(2):e1003479. doi:10.1371/journal.pcbi.1003479 . , Authors contributed equally.

Mech F, Wilson D, Lehnert T, Hube B, Figge MT (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytrometry Part A 85(3):126-139. doi:10.1002/cyto.a.22418

Mokhtari Z, Mech F, Zitzmann C, Hasenberg M, Gunzer M and Figge MT (2013) Automated characterization and parameter-free classification of cell tracks based on local migration behavior. PLoS One. 2013; 8(12): e80808. doi: 10.1371/journal.pone.0080808.

Zang E*, Brandes S*, Tovar M, Martin K, Mech F, Horbert P, Henkel T, Figge MT, Roth M (2013) Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplet. Lab Chip 13(18), 3707 - 3713. doi: 10.1039/C3LC50572C *Authors contributed equally.

Coelho FM, Natale D, Soriano SF, Hons M, Swoger J, Mayer J, Danuser R, Scandella E, Pieczyk M, Zerwes HG, Junt T, Sailer AW, Ludewig B, Sharpe J, Figge MT, and Stein J (2013) Naïve B cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood 121:4101-4109. doi: 10.1182/blood-2012-10-465336

Zhang Y, Meyer-Hermann M, Geroge L, Figge MT, Khan M, Goodall M, Young SP, Reynolds A, Falciani F, Waisman A, Notley CA, Ehrenstein MR, Kosco-Vilbois M, Toellner KM (2013) Germinal center B cells govern their own fate via antibody feedback. J Exp Med 210:3 457-464. doi:10.1084/jem.20120150

Figge MT, Osiewacz HD, Reichert AS (2013) Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics? Bioessays 35:4 314-322. doi: 10.1002/bies.201200125

Guthke R, Linde J, Mech F, Figge MT (2013) Systems Biology of Microbial Infection. Front. Microbio. 3:328 (2012). doi: 10.3389/fmicb.2012.00328

Mech F, Figge MT Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence (2012) German Conference on Bioinformatics 2012, Highlight-Paper. Proceedings

Figge MT, Reichert AS, Meyer-Hermann M, Osiewacz HD (2012) Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging. PLoS Comput Biol 8(6):e1002576. doi:10.1371/journal.pcbi.1002576.

Tokarski C, Hummert S, Mech F, Figge MT, Germerodt S, Schroeter A and Schuster S (2012) Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi. Front. Microbio. 3:129. doi: 10.3389/fmicb.2012.00129.

Horn F, Heinekamp T, Kniemeyer O, Pollmächer J, Valiante V, Brakhage AA (2012) Systems biology of fungal infection. Front. Microbio. 3:108. doi:10.3389/fmicb.2012.00108.

Mech F*, Thywißen A*, Guthke R, Brakhage AA, Figge MT (2011) Automated Image Analysis of the Host-Pathogen Interaction between Phagocytes and Aspergillus fumigatus. PLoS ONE 6(5):e19591. doi:10.1371/journal.pone.0019591 *Authors contributed equally.

Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner K-M, Elson G, Kosco-Vilbois MH (2010) Toll-Like Receptor 4 signaling by FDC is pivotal for delivering the consequences of germinal center responses Immunity 33:84-95.

Fatehi H, Meyer-Hermann M, and Figge MT (2010) Modelling cellular aggregation induced by chemotaxis and phototaxis. Mathematical Medicine and Biology 27:373-384.

M.T. Figge (2009) Optimization of immunoglobulin substitution therapy by a stochastic immune response model. PLoS ONE 4(5):e5685 doi: 10.1371/journal.pone.0005685.

Meyer-Hermann M, Figge MT, and Straub RH (2009) Mathematical modeling of circadian rhythm of key neuroendocrine immune players in rheumatoid arthritis: A systems biology approach. Arthritis & Rheumatism 60:2585-2594.

Meyer-Hermann M, Figge MT, and Toellner K-M (2009) Germinal centres seen through the mathematical eye: B cell models on the catwalk. Trends in Immunology 30:157-164.

Figge MT and Meyer-Hermann M (2009) Modeling receptor-ligand binding kinetics in immunological synapse formation. European Physical Journal D 51:153-160, topical issue "Bio Macromolecules".

Figge MT, Garin A, Gunzer M, Kosco-Vilbois M, Toellner K-M, and Meyer-Hermann M (2008) Deriving a germinal center lymphocyte migration model from two-photon data. Journal of Experimental Medicine 205:3019-3029.

Figge MT and Meyer-Hermann M (2006) Geometrically Repatterned Immunological Synapses Uncover Formation Mechanisms. PLoS Computational Biology 2:e171.

Figge MT (2005) Stochastic Discrete Event Simulation of Germinal Center Reactions.Physical Review E 71:051907 and Virtual Journal of Biological Physics Research 9(11).

Figge MT (2002) Statistical Model for Receptor-Ligand Binding Thermodynamics.Physical Review E 66:061901 and Virtual Journal of Biological Physics Research 4(12).


Books and Book Chapters
Guthke R, Linde J, Figge MT, Mech F (2012) Systems Biology of Microbial Infection. Frontiers Media SA, ISBN: 978-2-88919-060-7.

Figge MT and Meyer-Hermann M (2011) Modelling intravital two-photon data of lymphocyte migration and interaction. In Molina-Pais C and Lythe G (Eds.) Mathematical Models and Immune Cell Biology, Springer, ISBN: 978-1-4419-7724-3 .