Research Group: Applied Systems Biology
Publications
Publications
Selected Research Papers
"Naïve B cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions.",
Fernanda Matos Coelho, Daniela Natale, Silvia F Soriano, Miroslav Hons, Jim Swoger, Juergen Mayer, Renzo Danuser, Elke Scandella, Markus Pieczyk, Hans Guenter Zerwes, Tobias Junt, Andreas W Sailer, Burkhard Ludewig, James Sharpe, Marc Thilo Figge, and Jens SteinBlood (2013). doi: 10.1182/blood-2012-10-465336"Germinal center B cells govern their own fate via antibody feedback.",
Zhang Y, Meyer-Hermann M, Geroge L, Figge MT, Khan M, Goodall M, Young SP, Reynolds A, Falciani F, Waisman A, Notley CA, Ehrenstein MR, Kosco-Vilbois M, Toellner KMJ Exp Med (2013). doi:10.1084/jem.20120150"Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics?",
Figge MT, Osiewacz HD, Reichert ASBioessays (2013). doi: 10.1002/bies.201200125"Systems Biology of Microbial Infection.",
Guthke R, Linde J, Mech F, Figge MT Front. Microbio. 3:328 (2012). doi: 10.3389/fmicb.2012.00328"Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence.",Mech F, Figge MT German Conference on Bioinformatics 2012, Highlight-Paper (2012). Proceedings
"Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging.",
Marc Thilo Figge, Andreas S. Reichert, Michael Meyer-Hermann, Heinz D. Osiewacz,PLoS Comput Biol 8(6): e1002576 (2012). doi:10.1371/journal.pcbi.1002576
"Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi.",
Tokarski C, Hummert S, Mech F, Figge M T, Germerodt S, Schroeter A and Schuster S,Front. Microbio. 3:129 (2012). doi: 10.3389/fmicb.2012.00129
"Systems biology of fungal infection",
F. Horn, T. Heinekamp, O. Kniemeyer, J. Pollmächer, V. Valiante, A.A. Brakhage,
Front. Microbio. 3:108 (2012). doi:10.3389/fmicb.2012.00108
"Automated Image Analysis of the Host-Pathogen Interaction between Phagocytes and Aspergillus fumigatus",
F. Mech, A. Thywißen, R. Guthke, A.A. Brakhage, M.T. Figge,
PLoS ONE 6(5): e19591 (2011).doi:10.1371/journal.pone.0019591
"Toll-Like Receptor 4 signaling by FDC is pivotal for delivering the consequences of germinal center responses",
A. Garin, M. Meyer-Hermann, M. Contie, M.T. Figge, V. Buatois, M. Gunzer, K.-M. Toellner, G. Elson, M.H. Kosco-Vilbois,
Immunity 33, 84-95 (2010).
"Modelling cellular aggregation induced by chemotaxis and phototaxis",
H. Fatehi, M. Meyer-Hermann, and M.T. Figge,
Mathematical Medicine and Biology 27, 373-384 (2010).
"Optimization of immunoglobulin substitution therapy by a stochastic immune response model",
M.T. Figge,
PLoS ONE 4 (5), e5685 (2009).
"Mathematical modeling of circadian rhythm of key neuroendocrine immune players in rheumatoid arthritis: A systems biology approach",
M. Meyer-Hermann, M.T. Figge, and Rainer H. Straub,
Arthritis & Rheumatism 60, 2585-2594 (2009).
"Germinal centres seen through the mathematical eye: B cell models on the catwalk",
M. Meyer-Hermann, M.T. Figge, and K.-M. Toellner,
Trends in Immunology 30, 157-164 (2009).
"Modeling receptor-ligand binding kinetics in immunological synapse formation",
M.T. Figge and M. Meyer-Hermann,
European Physical Journal D 51, 153-160, topical issue "Bio Macromolecules" (2009).
"Deriving a germinal center lymphocyte migration model from two-photon data",
M.T. Figge, A. Garin, M. Gunzer, M. Kosco-Vilbois, K.-M. Toellner, and M. Meyer-Hermann,
Journal of Experimental Medicine 205, 3019-3029 (2008).
"Geometrically Repatterned Immunological Synapses Uncover Formation Mechanisms",
M.T. Figge and M. Meyer-Hermann,
PLoS Computational Biology 2, e171 (2006).
"Stochastic Discrete Event Simulation of Germinal Center Reactions",
M.T. Figge,
Physical Review E 71, 051907 (2005) and
Virtual Journal of Biological Physics Research 9 (11), (2005).
"Statistical Model for Receptor-Ligand Binding Thermodynamics",
M.T. Figge,
Physical Review E 66, 061901 (2002) and
Virtual Journal of Biological Physics Research 4 (12), (2002).
Fernanda Matos Coelho, Daniela Natale, Silvia F Soriano, Miroslav Hons, Jim Swoger, Juergen Mayer, Renzo Danuser, Elke Scandella, Markus Pieczyk, Hans Guenter Zerwes, Tobias Junt, Andreas W Sailer, Burkhard Ludewig, James Sharpe, Marc Thilo Figge, and Jens SteinBlood (2013). doi: 10.1182/blood-2012-10-465336"Germinal center B cells govern their own fate via antibody feedback.",
Zhang Y, Meyer-Hermann M, Geroge L, Figge MT, Khan M, Goodall M, Young SP, Reynolds A, Falciani F, Waisman A, Notley CA, Ehrenstein MR, Kosco-Vilbois M, Toellner KMJ Exp Med (2013). doi:10.1084/jem.20120150"Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics?",
Figge MT, Osiewacz HD, Reichert ASBioessays (2013). doi: 10.1002/bies.201200125"Systems Biology of Microbial Infection.",
Guthke R, Linde J, Mech F, Figge MT Front. Microbio. 3:328 (2012). doi: 10.3389/fmicb.2012.00328"Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence.",Mech F, Figge MT German Conference on Bioinformatics 2012, Highlight-Paper (2012). Proceedings
"Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging.",
Marc Thilo Figge, Andreas S. Reichert, Michael Meyer-Hermann, Heinz D. Osiewacz,PLoS Comput Biol 8(6): e1002576 (2012). doi:10.1371/journal.pcbi.1002576
"Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi.",
Tokarski C, Hummert S, Mech F, Figge M T, Germerodt S, Schroeter A and Schuster S,Front. Microbio. 3:129 (2012). doi: 10.3389/fmicb.2012.00129
"Systems biology of fungal infection",
F. Horn, T. Heinekamp, O. Kniemeyer, J. Pollmächer, V. Valiante, A.A. Brakhage,
Front. Microbio. 3:108 (2012). doi:10.3389/fmicb.2012.00108
"Automated Image Analysis of the Host-Pathogen Interaction between Phagocytes and Aspergillus fumigatus",
F. Mech, A. Thywißen, R. Guthke, A.A. Brakhage, M.T. Figge,
PLoS ONE 6(5): e19591 (2011).doi:10.1371/journal.pone.0019591
"Toll-Like Receptor 4 signaling by FDC is pivotal for delivering the consequences of germinal center responses",
A. Garin, M. Meyer-Hermann, M. Contie, M.T. Figge, V. Buatois, M. Gunzer, K.-M. Toellner, G. Elson, M.H. Kosco-Vilbois,
Immunity 33, 84-95 (2010).
"Modelling cellular aggregation induced by chemotaxis and phototaxis",
H. Fatehi, M. Meyer-Hermann, and M.T. Figge,
Mathematical Medicine and Biology 27, 373-384 (2010).
"Optimization of immunoglobulin substitution therapy by a stochastic immune response model",
M.T. Figge,
PLoS ONE 4 (5), e5685 (2009).
"Mathematical modeling of circadian rhythm of key neuroendocrine immune players in rheumatoid arthritis: A systems biology approach",
M. Meyer-Hermann, M.T. Figge, and Rainer H. Straub,
Arthritis & Rheumatism 60, 2585-2594 (2009).
"Germinal centres seen through the mathematical eye: B cell models on the catwalk",
M. Meyer-Hermann, M.T. Figge, and K.-M. Toellner,
Trends in Immunology 30, 157-164 (2009).
"Modeling receptor-ligand binding kinetics in immunological synapse formation",
M.T. Figge and M. Meyer-Hermann,
European Physical Journal D 51, 153-160, topical issue "Bio Macromolecules" (2009).
"Deriving a germinal center lymphocyte migration model from two-photon data",
M.T. Figge, A. Garin, M. Gunzer, M. Kosco-Vilbois, K.-M. Toellner, and M. Meyer-Hermann,
Journal of Experimental Medicine 205, 3019-3029 (2008).
"Geometrically Repatterned Immunological Synapses Uncover Formation Mechanisms",
M.T. Figge and M. Meyer-Hermann,
PLoS Computational Biology 2, e171 (2006).
"Stochastic Discrete Event Simulation of Germinal Center Reactions",
M.T. Figge,
Physical Review E 71, 051907 (2005) and
Virtual Journal of Biological Physics Research 9 (11), (2005).
"Statistical Model for Receptor-Ligand Binding Thermodynamics",
M.T. Figge,
Physical Review E 66, 061901 (2002) and
Virtual Journal of Biological Physics Research 4 (12), (2002).
Books and Book Chapters
"Systems Biology of Microbial Infection.",
Reinhard Guthke, Jörg Linde, Marc Thilo Figge, Franziska Mech Publisher: Frontiers Media SA, ISBN: 978-2-88919-060-7, (2012)"Modelling intravital two-photon data of lymphocyte migration and interaction",
M.T. Figge and M. Meyer-Hermann,
book chapter in "Mathematical Models and Immune Cell Biology", Springer, ISBN 978-1-4419-7724-3, (2011).
Reinhard Guthke, Jörg Linde, Marc Thilo Figge, Franziska Mech Publisher: Frontiers Media SA, ISBN: 978-2-88919-060-7, (2012)"Modelling intravital two-photon data of lymphocyte migration and interaction",
M.T. Figge and M. Meyer-Hermann,
book chapter in "Mathematical Models and Immune Cell Biology", Springer, ISBN 978-1-4419-7724-3, (2011).

