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MAP kinase cascades in fungal virulence: From signals to pathogenicity response
Fungi have a devastating impact on agriculture and human health. Every year, billions of Euros worth of agricultural production is lost to fungal disease. Human fungal infections have lethal consequences for a growing population of immuno-compromised patients, and today represent as much as 15% of the total of hospital-acquired infections. The single most limiting factor in the development of improved fungicides and medical antifungals is the lack of effective tools for the identification of novel targets. Such antifungal targets tend to be evolutionary conserved among plant and human pathogenic fungi. This is particularly relevant for conserved biological pathways such as signal transduction cascades.
The SIGNALPATH network focuses on the role of mitogen-activated protein kinase (MAPK) cascades in fungal pathogenicity. MAPK cascades are highly conserved signalling modules that are key players in fungal infection of plants and humans. The main objective of SIGNALPATH is to understand how fungal MAPK cascades sense and transduce external signals to trigger the cellular responses that lead to infection. This knowledge can will be applied to the identification of novel antifungal targets.
SIGNALPATH reaches across the boundaries of traditionally separated fields such as plant pathology, medical microbiology, biochemistry, cell cycle research, and computational biology to assemble a multidisciplinary and intersectorial team composed of 7 research groups and 2 world-class companies from 6 different EU countries. This dynamic knowledge platform provides the scenario for training of 6 early-stage and 3 experienced researchers in a set of skills that link fungal biology, signal transduction and bioinformatics-driven research.
SIGNALPATH Homepage
MAP kinase cascades in fungal virulence: From signals to pathogenicity response
Fungi have a devastating impact on agriculture and human health. Every year, billions of Euros worth of agricultural production is lost to fungal disease. Human fungal infections have lethal consequences for a growing population of immuno-compromised patients, and today represent as much as 15% of the total of hospital-acquired infections. The single most limiting factor in the development of improved fungicides and medical antifungals is the lack of effective tools for the identification of novel targets. Such antifungal targets tend to be evolutionary conserved among plant and human pathogenic fungi. This is particularly relevant for conserved biological pathways such as signal transduction cascades.
The SIGNALPATH network focuses on the role of mitogen-activated protein kinase (MAPK) cascades in fungal pathogenicity. MAPK cascades are highly conserved signalling modules that are key players in fungal infection of plants and humans. The main objective of SIGNALPATH is to understand how fungal MAPK cascades sense and transduce external signals to trigger the cellular responses that lead to infection. This knowledge can will be applied to the identification of novel antifungal targets.
SIGNALPATH reaches across the boundaries of traditionally separated fields such as plant pathology, medical microbiology, biochemistry, cell cycle research, and computational biology to assemble a multidisciplinary and intersectorial team composed of 7 research groups and 2 world-class companies from 6 different EU countries. This dynamic knowledge platform provides the scenario for training of 6 early-stage and 3 experienced researchers in a set of skills that link fungal biology, signal transduction and bioinformatics-driven research.
SIGNALPATH Homepage
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