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Departments
Research Group: Systems Biology / Bioinformatics
Research Group: Systems Biology / Bioinformatics
Mission:
The goal in systems biology and bioinformatics is to discover structures and to understand the dynamics of biological systems by data-based and purpose-driven modeling. Systems biological research at the HKI is dedicated to the integrated analysis of transcriptome and proteome as well as microbiological and clinical data. Data analysis comprises storage and management of heterogeneous experimental data in a data warehouse, data pre-processing, discovery of the main features and patterns and – finally – generation of testable model hypotheses. The hypotheses have been embedded in predictive mathematical and computational models that represent
(i) the available expert knowledge,
(ii) facts extracted from biological databases and
(iii) the hypotheses generated by experimental data analysis.
The data analysis pipeline at the HKI is focused on the generation of quantitative dynamic and/or qualitative temporal models that are generated from time series data by dynamic data mining techniques. Some of these techniques have been developed – in collaboration with other groups – by our own work.
The Group represents the Institute in the Jena Centre for Bioinfomatics.
International Workshop 2010:
"Systems Biology for Industry: Dynamics and regulation of the metabolic balance in Escherichia coli"
Jena, October 7-8, 2010
The Workshop will be the 8th in a series of annual International Workshops held in Jena and organized by our research group. It is dedicated to the dynamic modelling of the overflow metabolism of Escherichia coli that limits both biomass yield and the quality of biotechnologically important products. The quantitative modelling of the regulation of metabolic fluxes around the pyruvate node, in particular the minimization of by-product formation is a pre-requisite for optimizing recombinant protein production by E. coli. The workshop is part of our FORSYS-partner project "Dynamics and regulation of the metabolic balance in Escherichia coli" and will bring together the partners from academia and partners from the pharmaceutical and biotechnological industry.
Contact: reinhard.guthke [at] hki-jena.de
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