OXISYS ( BMBF-Programe GerontoSys II)
 

OXISYS - Role of oxidative injury in aging and therapeutic implications

The role of oxidative stress by reactive oxygen species (ROS) in aging processes will be studied in both animal models (rat) and human. Experiments will be designed from already established in silico models. Quantitative data from in vivo and in vitro experiments will be analysed and modelled. The analysis of inferred genome-wide network models will be focussed on aging-associated and oxidative injury-induced alterations and the role of the mTOR pathway in aging processes. The in silico models shall describe aging-related change of parameters and structural features of gene regulatory and signalling networks. Predictive in silico models shall be used to identify potential biomarkers for ROS-associated aging that shall support personalized strategies for healthy aging of the individuals.

With an ever-ageing human population, aging-associated physiological alterations and diseases, including oxidative injury and subsequent functional impairment, will have a growing impact on our health services in the future. The proposed project “Role of oxidative injury in aging and therapeutic implications” aims at solving problems of medical relevance with respect to more personalized health care of the aging human.


Personnel:
Dr. Uwe Menzel
Wolfgang Schmidt-Heck

Cooperation:
* Dr. Katrin Zeilinger (Charitè Universitätsmedizin Berlin, Koordination)
* Dr. Ursula Müller-Viera (Pharmacelsus GmbH, Saarbrücken)
* Prof. A. Nüssler (TU München)
* Prof. E. Heinzle (Universität des Saarlandes)
* Dr. D. Müller (Insilico Biotechnology AG, Stuttgart)